Differential cis-regulation of human versus mouse <i>TERT</i> gene expression <i>in vivo</i> : Identification of a human-specific repressive element

Abstract excerpt

In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire hTERT (human telomerase reverse transcriptase) gene was introduced in mice. In these transgenic mice, expression of the hTERT transgene was similar to that of endogenous hTERT in humans, rather than endogenous mTERT...

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