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Article

Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

Genome medicine - 8 Jun 2018

Li Zeran, Del-Aguila Jorge L, Dube Umber, Budde John, Martinez Rita, Black Kathleen, Xiao Qingli, Cairns Nigel J, Dougherty Joseph D, Lee Jin-Moo, Morris John C, Bateman Randall J, Karch Celeste M, Cruchaga Carlos, Harari Oscar

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored. METHODS: We developed and optimized a cell-type-specific expression reference panel and employed digital deconvolution methods to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29880032
DOI: 10.1186/s13073-018-0551-4
PMCID: PMC5992755

Genes

APOE
APP
PSEN1
PSEN2
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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