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Article

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression.

PLoS computational biology - 1 Aug 2020

Patrick Ellis, Taga Mariko, Ergun Ayla, Ng Bernard, Casazza William, Cimpean Maria, Yung Christina, Schneider Julie A, Bennett David A, Gaiteri Chris, De Jager Philip L, Bradshaw Elizabeth M, Mostafavi Sara

Abstract excerpt

Complexity of cell-type composition has created much skepticism surrounding the interpretation of bulk tissue transcriptomic studies. Recent studies have shown that deconvolution algorithms can be applied to computationally estimate cell-type proportions from gene expression data of bulk blood samples, but their performance when applied to brain tissue is unclear. Here, we have generated an immunohistochemistry...

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Identifiers

PMID: 32804935
DOI: 10.1371/journal.pcbi.1008120
PMCID: PMC7451979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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