Article

Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells

2022-08-15

Abstract excerpt

<h4>ABSTRACT</h4> Lipids play vital roles in cellular homeostasis and regulate pluripotency of human stem cells. However, the impact of lipids on murine pluripotent stem cells is unclear. While Mek1/2 and Gsk3β inhibition (“2i”) supports the maintenance of murine embryonic stem cells (ESCs) in a homogenous naïve state, prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmenta...

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Literature Corpus work: 39073922-9d6b-5790-b40a-75f78fca3ff6
DOI: 10.1101/2022.08.12.503780

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