Article

A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe Syndrome

2021-08-19

Abstract excerpt

Human brain development is a complex process where multiple cellular and developmental events are co-ordinated to generate normal structure and function. Alteration in any of these events can impact brain development, manifesting clinically as neurodevelopmental disorders. Human genetic disorders of lipid metabolism often present with features of altered brain function. Lowe syndrome (LS), is a X-linked recessive...

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Literature Corpus work: e6fe1e1b-a8a4-54d4-bc80-f4a7409ea143
DOI: 10.1101/2021.08.19.456986

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