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Article

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2017

Hawkins Kate E, Moschidou Dafni, Faccenda Danilo, Wruck Wasco, Martin-Trujillo Alex, Hau Kwan-Leong, Ranzoni Anna Maria, Sanchez-Freire Veronica, Tommasini Fabio, Eaton Simon, De Coppi Paolo, Monk David, Campanella Michelangelo, Thrasher Adrian J, Adjaye James, Guillot Pascale V

Abstract excerpt

Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells. We previously demonstrated that VPA_AFS cells, human amniocytes cultivated with valproic acid (VPA) acquired functional pluripotency while remaining distinct from human embryonic stem cells (hESCs), questioning the relationship...

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Identifiers

PMID: 28153093
DOI: 10.1016/j.ymthe.2016.11.014
PMCID: PMC5368475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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