Article

Distinct phospho-variants of STAT3 regulate naïve pluripotency and developmental pace <i>in vivo</i>

2022-03-08

Abstract excerpt

STAT3 has been studied extensively in the context of self-renewal of naïve pluripotent mouse embryonic stem cells. We uncovered acute roles for STAT3 and its target, TFCP2L1, in maintenance of epiblast and primitive endoderm during in vivo diapause. On an outbred genetic background, we observed consistent developmental retardation from implantation until embryonic day 11.5, beginning with significant reduction of...

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Literature Corpus work: 0d02f304-ab46-5887-a799-60dd0d816210
DOI: 10.1101/2022.03.08.483469

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