Article

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

2022-01-21

Abstract excerpt

<h4>ABSTRACT</h4> The expression of the pluripotency factors OCT4, SOX2, KLF4 and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem cells in a process known as reprogramming. Notably, cycles of brief OSKM expression do not change cell identity but can reverse markers of aging in cells and extend longevity in progeroid mice. However, little is known about the mechanisms involved. Here, we h...

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Literature Corpus work: 54e4902b-6e40-5d35-8b04-83a8ced00461
DOI: 10.1101/2022.01.20.477063

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