Article

TRiPPing the sensors: The osmosensing pathway of Polycystin 2

2023-05-12

Abstract excerpt

Mutations to polycystin-2 (PC2), a non-selective cation permeant transient receptor potential channel, results in polycystic kidney disease (PKD). Despite the disease relevance of PC2, the physiological agonist that activates PC2 has remained elusive. As one of the earliest symptoms in PKD is a urine concentrating deficiency, we hypothesized that shifts in osmolarity experienced by the collecting duct cells would...

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Literature Corpus work: 38f1d198-a1b4-5fe7-8f76-96dd1a1882a5
DOI: 10.1101/2023.05.09.540007

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