Article
Polycystin 2 is increased in disease to protect against stress-induced cell death.
Scientific reports - 15 Jan 2020
Brill Allison L, Fischer Tom T, Walters Jennifer M, Marlier Arnaud, Sewanan Lorenzo R, Wilson Parker C, Johnson Eric K, Moeckel Gilbert, Cantley Lloyd G, Campbell Stuart G, Nerbonne Jeanne M, Chung Hee Jung, Robert Marie E, Ehrlich Barbara E
Abstract excerpt
Polycystin 2 (PC2 or TRPP1, formerly TRPP2) is a calcium-permeant Transient Receptor Potential (TRP) cation channel expressed primarily on the endoplasmic reticulum (ER) membrane and primary cilia of all cell and tissue types. Despite its ubiquitous expression throughout the body, studies of PC2 have focused primarily on its role in the kidney, as mutations in PC2 lead to the development of autosomal dominant...
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