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Regulation of calcium signaling by polycystin-2

6 May 2004

Abstract excerpt

Autosomal dominant PKD (ADPKD) is a common lethal genetic disorder characterized by progressive development of fluid-filled cysts in the kidney and other target organs. ADPKD is caused by mutations in the PKD1 and PKD2 genes, encoding the transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Although the function and putative interacting ligands of PC1 are largely unknown, recent...

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PMID: 15130895
DOI: 10.1152/ajprenal.00181.2003

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