Article
Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 2016
Arif Pavel Mahmud, Lv Caixia, Ng Courtney, Yang Lei, Kashyap Parul, Lam Clarissa, Valentino Victoria, Fung Helen Y, Campbell Thomas, Møller Simon Geir, Zenisek David, Holtzman Nathalia G, Yu Yong
Abstract excerpt
Mutations in polycystin-1 and transient receptor potential polycystin 2 (TRPP2) account for almost all clinically identified cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. TRPP2 functions as a cation channel in its homomeric complex and in the TRPP2/polycystin-1 receptor/ion channel complex. The activation mechanism of TRPP2 is unknown, which...
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