Article
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.
The EMBO journal - 23 Feb 2005
Köttgen Michael, Benzing Thomas, Simmen Thomas, Tauber Robert, Buchholz Björn, Feliciangeli Sylvain, Huber Tobias B, Schermer Bernhard, Kramer-Zucker Albrecht, Höpker Katja, Simmen Katia Carmine, Tschucke Christoph Carl, Sandford Richard, Kim Emily, Thomas Gary, Walz Gerd
Abstract excerpt
The trafficking of ion channels to the plasma membrane is tightly controlled to ensure the proper regulation of intracellular ion homeostasis and signal transduction. Mutations of polycystin-2, a member of the TRP family of cation channels, cause autosomal dominant polycystic kidney disease, a disorder characterized by renal cysts and progressive renal failure. Polycystin-2 functions as a calcium-permeable...
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