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Article

TRPP2 and TRPV4 form a polymodal sensory channel complex

11 Aug 2008

Abstract excerpt

The primary cilium has evolved as a multifunctional cellular compartment that decorates most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular mechanisms that convert the deflection of cilia into intracellular calcium transients have remained elusive. Polycystin-2 (TRPP2), an ion channel mutated in polycystic kidney disease, is required for cilia-mediated calcium transients but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18695040
DOI: 10.1083/jcb.200805124

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