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Article

Genetic Regulation of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Plasma Levels and Its Impact on Atherosclerotic Vascular Disease Phenotypes.

Circulation. Genomic and precision medicine - 1 May 2018

Pott Janne, Schlegel Valentin, Teren Andrej, Horn Katrin, Kirsten Holger, Bluecher Christina, Kratzsch Juergen, Loeffler Markus, Thiery Joachim, Burkhardt Ralph, Scholz Markus

Abstract excerpt

BACKGROUND: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9) is a novel strategy to treat hypercholesterolemia and reduce cardiovascular events. However, the potential role of circulating plasma PCSK9 concentrations as a diagnostic and predictive biomarker remains uncertain as of now. Here, we aimed to identify genetic variants associated with plasma PCSK9 and investigate possible causal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29748315
DOI: 10.1161/CIRCGEN.117.001992

Genes

PCSK9

Variants

rs11591147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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