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Article

PCSK9 Protein and rs562556 Polymorphism Are Associated With Arterial Plaques in Healthy Middle-Aged Population: The STANISLAS Cohort.

Journal of the American Heart Association - 7 Apr 2020

Ferreira João Pedro, Xhaard Constance, Lamiral Zohra, Borges-Canha Marta, Neves João Sérgio, Dandine-Roulland Claire, LeFloch Edith, Deleuze Jean-François, Bacq-Daian Delphine, Bozec Erwan, Girerd Nicolas, Boivin Jean-Marc, Zannad Faiez, Rossignol Patrick

Abstract excerpt

Background PCSK9 (Proprotein convertase subtilisin/kexin type 9) binds low-density lipoprotein receptor, preventing its recycling. PCSK9 is a risk predictor and a biotarget in atherosclerosis. The PCSK9-rs562556 variant has been reported as a gain-of-function mutation. The aim of this study was to determine whether the PCSK9-low-density lipoprotein receptor-rs562556 axis is associated with carotid artery plaques...

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Identifiers

PMID: 32208829
DOI: 10.1161/JAHA.119.014758
PMCID: PMC7428603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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