Article

Cryo-EM structure of the human TACAN channel in a closed state

2021-08-24

Abstract excerpt

TACAN is an ion channel involved in sensing mechanical pain. It has recently been shown to represent a novel and evolutionarily conserved class of mechanosensitive channels. Here, we present the cryoelectron microscopic structure of human TACAN (hTACAN). hTACAN forms a dimer in which each protomer consists of a transmembrane globular domain (TMD) that is formed of six helices and an intracellular domain (ICD) that...

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Identifiers and source

Literature Corpus work: 38bdc02e-afde-5576-a736-5b912850125a
DOI: 10.1101/2021.08.23.457436

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