Article
A Calpha model for the transmembrane alpha helices of gap junction intercellular channels.
Molecular cell - 24 Sept 2004
Fleishman Sarel J, Unger Vinzenz M, Yeager Mark, Ben-Tal Nir
Abstract excerpt
Gap junction channels connect the cytoplasms of apposed cells via an intercellular conduit formed by the end-to-end docking of two hexameric hemichannels called connexons. We used electron cryomicroscopy to derive a three-dimensional density map at 5.7 angstroms in-plane and 19.8 angstroms vertical resolution, allowing us to identify the positions and tilt angles for the 24 alpha helices within each hemichannel....
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