Article

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

2021-06-17

Abstract excerpt

TMEM120A, a member of the Transmembrane protein 120 (TMEM120) family, has pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report that expression of TMEM120A is not sufficient in mediating poking- or stretch-induced currents in cells, and have solved cryo-EM structures of human TMEM120A ( Hs TMEM1...

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Literature Corpus work: e0611584-3106-59c0-9d83-32d2ef11caf4
DOI: 10.1101/2021.06.17.448797

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