Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.

eLife - 19 Aug 2021

Rong Yao, Jiang Jinghui, Gao Yiwei, Guo Jianli, Song Danfeng, Liu Wenhao, Zhang Mingmin, Zhao Yan, Xiao Bailong, Liu Zhenfeng

Abstract excerpt

TMEM120A, a member of the transmembrane protein 120 (TMEM120) family, has a pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report that expression of TMEM120A is not sufficient in mediating poking- or stretch-induced currents in cells and have solved cryo-electron microscopy (cryo-EM) structures...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to CHO Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coenzyme A

Share to COS Cells

Share to Cricetulus

Share to Cryoelectron Microscopy

Share to HEK293 Cells

Share to Ion Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 34409941
DOI: 10.7554/eLife.71474
PMCID: PMC8480983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.PMID 34409941Read ↗

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cellsSemantic proximity Read ↗

Cryo-EM structure of the human TACAN channel in a closed stateSemantic proximity Read ↗

Mitochondrial COA7 is a heme-binding protein involved in the early stages of complex IV assemblySemantic proximity Read ↗

Insights into steroidogenic acute regulatory protein (StAR)-dependent cholesterol transfer in mitochondria: evidence from molecular modeling and structure-based thermodynamics supporting the existence of partially unfolded states of StAR.Semantic proximity Read ↗

TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels.Semantic proximity Read ↗

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2.Semantic proximity Read ↗

Cryo-EM structure of shutdown human non-muscle myosin 2ASemantic proximity Read ↗

Cryo-EM structure of shutdown human nonmuscle myosin 2A.Semantic proximity Read ↗

Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove.Semantic proximity Read ↗

Creatine kinase isoenzymes specificities: histidine 65 in human CK-BB, a role in protein stability, not in catalysis.Semantic proximity Read ↗

Characterization of six mutations in five Spanish patients with mitochondrial acetoacetyl-CoA thiolase deficiency: effects of amino acid substitutions on tertiary structure.Semantic proximity Read ↗

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.