Article

MLL4 is required for the first embryonic collective cell migration whereas MLL3 is not required until birth

2019-12-09

Abstract excerpt

Methylation of histone 3 lysine 4 (H3K4) is a major epigenetic system associated with gene expression. In mammals there are six H3K4 methyltransferases related to yeast Set1 and fly Trithorax, including two orthologs of fly Trithorax-related: MLL3 and MLL4. Exome sequencing has documented high frequencies of Mll3 and Mll4 mutations in many types of human cancer. Despite this emerging importance, the requirements...

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Literature Corpus work: 38b260e2-da02-55a9-8224-2cd6f432b502
DOI: 10.1101/870329

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