Article
Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.
Differentiation; research in biological diversity - 1 Jan 2000
Bourke L M, Del Monte-Nieto G, Outhwaite J E, Bharti V, Pollock P M, Simmons D G, Adam A, Hur S S J, Maghzal G J, Whitelaw E, Stocker R, Suter C M, Harvey R P, Harten S K
Abstract excerpt
Recently we reported that Rearranged L-Myc Fusion, RLF, acts as an epigenetic modifier maintaining low levels of DNA methylation at CpG island shores and enhancers across the genome. Here we focus on the phenotype of Rlf null mutant mice generated via an ENU mutagenesis screen, to identify genes required for epigenetic regulation. RLF is expressed in a range of fetal mouse tissues, including the fetal heart....
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