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Article

Paternal H3K4 methylation is required for minor zygotic gene activation and early mouse embryonic development.

EMBO reports - 1 Jul 2015

Aoshima Keisuke, Inoue Erina, Sawa Hirofumi, Okada Yuki

Abstract excerpt

Epigenetic modifications, such as DNA methylation and histone modifications, are dynamically altered predominantly in paternal pronuclei soon after fertilization. To identify which histone modifications are required for early embryonic development, we utilized histone K-M mutants, which prevent endogenous histone methylation at the mutated site. We prepared four single K-M mutants for histone H3.3, K4M, K9M,...

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Identifiers

PMID: 25925669
DOI: 10.15252/embr.201439700
PMCID: PMC4515120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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