Article

An ARID3A-dependent progenitor lineage confers developmental robustness to palate morphogenesis

2026-02-24

Abstract excerpt

<title>Abstract</title> <p>The periderm prevents pathological adhesions during orofacial development, yet its lineage origins remain unresolved. Here, we define the murine palatal epithelial hierarchy, identifying a transient, ARID3A-defined K5+;K14– progenitor subpopulation programmed for periderm differentiation. Genetic ablation of Arid3a impairs this lineage, causing severe delay in palate closure rather than...

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Literature Corpus work: 8b9aec3d-63c6-5b46-b3eb-fd3c7657eb5c
DOI: 10.21203/rs.3.rs-8871167/v1

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