Article
MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.
Development (Cambridge, England) - 17 Jun 2020
Ashokkumar Deepthi, Zhang Qinyu, Much Christian, Bledau Anita S, Naumann Ronald, Alexopoulou Dimitra, Dahl Andreas, Goveas Neha, Fu Jun, Anastassiadis Konstantinos, Stewart A Francis, Kranz Andrea
Abstract excerpt
Methylation of histone 3 lysine 4 (H3K4) is a major epigenetic system associated with gene expression. In mammals there are six H3K4 methyltransferases related to yeast Set1 and fly Trithorax, including two orthologs of fly Trithorax-related: MLL3 and MLL4. Exome sequencing has documented high frequencies of MLL3 and MLL4 mutations in many types of human cancer. Despite this emerging importance, the requirements...
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