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Article

Cas10 residues lining the target RNA binding channel regulate interference by distinguishing cognate target RNA from mismatched targets.

RNA biology - 1 Dec 2026

Khweis Sarah A, Blackburn Mason A, Perdigao Calvin C, Pierce Megan O, Lewis Colby R, Dunkle Jack A

Abstract excerpt

Type III CRISPR systems are defined by the presence of the Cas10 protein and are among the most abundant CRISPR systems in nature. Cas10 forms a complex with crRNA and several Cas proteins that surveils prokaryotic cells for foreign RNA molecules and when they are detected it activates a cascade of interference activities. The synthesis of the cyclic oligoadenylate signalling molecule by Cas10 is a key aspect of...

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Identifiers

PMID: 41704216
DOI: 10.1080/15476286.2026.2633385
PMCID: PMC12934148

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