Article

Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds

2023-05-09

Abstract excerpt

Neurodegenerative tauopathies are caused by transition of tau protein from a monomer to a toxic aggregate. They include Alzheimer disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick disease (PiD). We have previously proposed that tau monomer exists in two conformational ensembles: an inert form (M i ), which does not self-assemble; and seed-competent form (M s ), which s...

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Literature Corpus work: 38975a1f-f1d9-5b0e-86f1-86251fa81a0f
DOI: 10.1101/2023.05.04.539475

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