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Preclinical characterization and IND‐enabling safety studies for PNT001, an antibody that recognizes <i>cis</i>‐pT231 tau

1 Apr 2023

Abstract excerpt

BACKGROUND: The cis-conformer of tau phosphorylated at threonine-231 (cis-pT231 tau) is hypothesized to contribute to tauopathies. PNT001 is a humanized, monoclonal antibody that recognizes cis-pT231 tau. PNT001 was characterized to assess clinical development readiness. METHODS: Affinity and selectivity were assessed by surface plasmon resonance and enzyme-linked immunosorbent assay. Immunohistochemistry (IHC)...

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PMID: 37002928
DOI: 10.1002/alz.13028

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