Article

Somatic mutation and selection at epidemiological scale

2024-11-01

Abstract excerpt

As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ( 1–10 . Some of these clones represent a first step towards cancer whereas others may contribute to ageing and other diseases. However, our understanding of the clonal landscapes of human tissues, and their impact on cancer risk, ageing and disease, remains limited due to the challenge of detecting somatic mutations p...

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Literature Corpus work: 0ce7c0bb-f0c9-5fcc-95fd-b22cb1681be7
DOI: 10.1101/2024.10.30.24316422

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