Somatic mutation and selection at population scale.

doi:10.1038/s41586-025-09584-w

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Article

Somatic mutation and selection at population scale.

Nature - 1 Nov 2025

Lawson Andrew R J, Abascal Federico, Nicola Pantelis A, Lensing Stefanie V, Roberts Amy L, Kalantzis Georgios, Baez-Ortega Adrian, Brzozowska Natalia, El-Sayed Moustafa Julia S, Vaitkute Dovile, Jakupovic Belma, Nessa Ayrun, Wadge Samuel, Österdahl Marc F, Paterson Anna L, Rassl Doris M, Alcantara Raul E, O'Neill Laura, Widaa Sara, Austin-Guest Siobhan, Neville Matthew D C, Przybilla Moritz J, Cheng Wei, Morra Maria, Sykes Lucy, Mayho Matthew, Müller-Sienerth Nicole, Williams Nicholas, Alexander Diana, Harvey Luke M R, Clarke Thomas, Byrne Alex, Blundell Jamie R, Young Matthew D, Mahbubani Krishnaa T A, Saeb-Parsy Kourosh, Martin Hilary C, Stratton Michael R, Campbell Peter J, Rahbari Raheleh, Small Kerrin S, Martincorena Iñigo

Abstract excerpt

As we age, many tissues become colonized by microscopic clones carrying somatic driver mutations1-7. Some of these clones represent a first step towards cancer whereas others may contribute to ageing and other diseases. However, our understanding of this phenomenon remains limited due to the challenge of detecting mutations in small clones. Here we introduce a new version of nanorate sequencing (NanoSeq)8, a...

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Identifiers

PMID: 41062696
DOI: 10.1038/s41586-025-09584-w
PMCID: PMC12611758

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