Article

A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma

2023-02-14

Abstract excerpt

Therapy Induced Senescence (TIS) leads to sustained growth arrest of cancer cells. The associated cytostasis has been shown to be reversible and cells escaping senescence further enhance the aggressiveness of cancers. Together with targeted therapeutics, senolytics, specifically targeting senescent cancer cells, constitute a promising avenue for improved cancer treatments. Understanding how cancer cells evade sene...

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Literature Corpus work: 386e8c73-39d3-5d7d-97f1-e9fef4b5584a
DOI: 10.1101/2023.02.13.528114

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