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Article

Integrative multi-omic analysis identified ERBB2 mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer.

Cancer biology & medicine - 7 Apr 2026

Zhao Yaxin, Wang Han, Wang Ying, Jiang Yizhou, Hu Xin, Shao Zhiming

Abstract excerpt

OBJECTIVE: The luminal androgen receptor (LAR) subtype of triple-negative breast cancer (TNBC) differentiation displays low proliferation yet strong metastatic potential and a poor chemotherapy response. This study aimed to define the molecular basis of the LAR subtype and identify actionable therapeutic targets. METHODS: Comprehensive multi-omic analyses were performed on the FUSCC-TNBC cohort, integrating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41968987
DOI: 10.20892/j.issn.2095-3941.2025.0691
PMCID: PMC13059881

Genes

ERBB2
PIK3CA
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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