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Intracellular signaling modules linking DNA damage to secretome changes in senescent melanoma cells

21 Apr 2020

Abstract excerpt

Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanocyte and melanoma cell senescence is likely to come into play as a key factor affecting the course...

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PMID: 32628430
DOI: 10.1097/cmr.0000000000000671

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