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Article

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression.

Cell reports - 5 Apr 2016

Katlinskaya Yuliya V, Katlinski Kanstantsin V, Yu Qiujing, Ortiz Angelica, Beiting Daniel P, Brice Angela, Davar Diwakar, Sanders Cindy, Kirkwood John M, Rui Hallgeir, Xu Xiaowei, Koumenis Constantinos, Diehl J Alan, Fuchs Serge Y

Abstract excerpt

Oncogene activation induces DNA damage responses and cell senescence. We report a key role of type I interferons (IFNs) in oncogene-induced senescence. IFN signaling-deficient melanocytes expressing activated Braf do not exhibit senescence and develop aggressive melanomas. Restoration of IFN signaling in IFN-deficient melanoma cells induces senescence and suppresses melanoma progression. Additional data from...

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Identifiers

PMID: 27052162
DOI: 10.1016/j.celrep.2016.03.006
PMCID: PMC4826807

Genes

IFNAR1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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