Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole‐exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells

17 Dec 2018

Abstract excerpt

We have extensively studied the phenotypic heterogeneity of patient‐derived melanoma cells. Here, whole‐exome sequencing revealed novel variants of genes associated with the MAPK, NOTCH, Hippo, cell‐cycle, senescence, and ubiquitin‐dependent pathways, which could contribute to the observed phenotypic diversity between cell lines. Focusing on mutations in the MAPK pathway‐associated genes, we found BRAF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cutaneous Melanoma Detection and Management
Share to Hippo pathway signaling and YAP/TAZ
Share to Melanoma and MAPK Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30556601
DOI: 10.1002/mc.22953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole‐exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cellsPMID 30556601Read ↗

Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma.Semantic proximity Read ↗

Genomic profiling with whole-exome sequencing revealed distinct mutations and novel pathways in Asian melanoma.Semantic proximity Read ↗

Genetic diversity in melanomagenesis: a comprehensive analysis of BRAF, NRAS, KIT and novel mutations across melanoma subtypes.Semantic proximity Read ↗

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.Semantic proximity Read ↗

Age-related next-generation sequencing mutational analysis in 1196 melanomas.Semantic proximity Read ↗

Distinct Mutation Patterns Reveal Melanoma Subtypes and Influence Immunotherapy Response in Advanced Melanoma PatientsSemantic proximity Read ↗

The landscape of gain and loss of function mutations in melanomaSemantic proximity Read ↗

BRAF alterations are associated with complex mutational profiles in malignant melanoma.Semantic proximity Read ↗

Comparative study on driver mutations in primary and metastatic melanomas at a single Japanese institute: A clue for intra- and inter-tumor heterogeneity.Semantic proximity Read ↗

Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.Semantic proximity Read ↗

Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.Semantic proximity Read ↗

High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.