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Article

Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype.

Oncotarget - 1 Dec 2013

Ohanna Mickaël, Cheli Yann, Bonet Caroline, Bonazzi Vanessa F, Allegra Marylin, Giuliano Sandy, Bille Karine, Bahadoran Philippe, Giacchero Damien, Lacour Jean Philippe, Boyle Glen M, Hayward Nicholas F, Bertolotto Corine, Ballotti Robert

Abstract excerpt

Here, we showed that the secretome of senescent melanoma cells drives basal melanoma cells towards a mesenchymal phenotype, with characteristic of stems illustrated by increased level of the prototype genes FN1, SNAIL, OCT4 and NANOG. This molecular reprogramming leads to an increase in the low-MITF and slow-growing cell population endowed with melanoma-initiating cell features. The secretome of senescent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24344100
DOI: 10.18632/oncotarget.1143
PMCID: PMC3926821

Genes

STAT3
AXL
MITF
NANOG

Provenance

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