Article
Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma.
Cancer discovery - 5 Oct 2022
Lin Youpei, Peng Lihua, Dong Liangqing, Liu Dongbing, Ma Jiaqiang, Lin Jian, Chen Xiaofang, Lin Penghui, Song Guohe, Zhang Mao, Liu Yuming, Rao Junhua, Wei Chen, Lu Ye, Zhang Shu, Ding Guangyu, Peng Zhenyu, Lu Haorong, Wang Xiaoying, Zhou Jian, Fan Jia, Wu Kui, Gao Qiang
Abstract excerpt
Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and an extremely high mortality rate. Here, we performed whole-exome sequencing, RNA sequencing, T-cell receptor (TCR) sequencing, and multiplexed immunofluorescence on 207 tumor regions from 45 patients with iCCA. Over half of iCCA displayed intratumoral heterogeneity of immune infiltration, and iCCA were classified into...
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