Article

Mitochondria-Targeted Oligomeric α-Synuclein Induces TOM40 Degradation and Mitochondrial Dysfunction in Parkinson’s Disease and Parkinsonism-Dementia of Guam

2024-02-21

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial dysfunction is a central aspect of Parkinson's disease (PD) pathology, yet the underlying mechanisms are not fully understood. This study investigates the link between α-Synuclein (α-Syn) pathology and the loss of translocase of the outer mitochondrial membrane 40 (TOM40), unraveling its implications for mitochondrial dysfunctions in neurons. We discovered that TOM40 prote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 386a3816-0a03-52a3-af98-97495de9e743
DOI: 10.21203/rs.3.rs-3970470/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondria-Targeted Oligomeric α-Synuclein Induces TOM40 Degradation and Mitochondrial Dysfunction in Parkinson’s Disease and Parkinsonism-Dementia of GuamDOI 10.21203/rs.3.rs-3970470/v1Read

ATPase Thorase Deficiency Causes α-synucleinopathy and Parkinson’s Disease-Like Behavior by Impairing PINK1/Parkin-Mediated MitophagySemantic proximity Read

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependentSemantic proximity Read

Alpha-synuclein at the intracellular and the extracellular side: functional and dysfunctional implications.Semantic proximity Read

Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models.Semantic proximity Read

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease modelsSemantic proximity Read

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial ParkinSemantic proximity Read

The Close Encounter Between Alpha-Synuclein and MitochondriaSemantic proximity Read

α-Synuclein pathology and mitochondrial dysfunction: Toxic partners in Parkinson's diseaseSemantic proximity Read

Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?Semantic proximity Read

Mitochondrial protein import regulates cytosolic protein homeostasis and neuronal integrity.Semantic proximity Read

Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein.Semantic proximity Read

Differential roles of proteasome and autophagy in α-synuclein and E46K oligomer clearance: insight into the modulatory effects of the dopamine metabolite DOPAC.Semantic proximity Read