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Article

Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models.

Acta neuropathologica - 1 Oct 2018

Shaltouki Atossa, Hsieh Chung-Han, Kim Min Joo, Wang Xinnan

Abstract excerpt

Alpha-synuclein is a component of Lewy bodies, the pathological hallmark of Parkinson's disease (PD), and is also mutated in familial PD. Here, by extensively analyzing PD patient brains and neurons, and fly models, we show that alpha-synuclein accumulation results in upregulation of Miro protein levels. Miro is a motor/adaptor on the outer mitochondrial membrane that mediates mitochondrial motility, and is...

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Identifiers

PMID: 29923074
DOI: 10.1007/s00401-018-1873-4
PMCID: PMC6123262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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