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Article

Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?

1 Sept 2017

Abstract excerpt

The distinctive pathological hallmarks of Parkinson's disease are the progressive death of dopaminergic neurons and the intracellular accumulation of Lewy bodies enriched in α-synuclein protein. Several lines of evidence from the study of sporadic, familial and pharmacologically induced forms of human Parkinson's disease also suggest that mitochondrial dysfunction plays an important role in disease progression....

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PMID: 28883016
DOI: 10.1242/dmm.026294

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