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Article

Mitochondrial protein import regulates cytosolic protein homeostasis and neuronal integrity.

Autophagy - 1 Jan 2018

Liu Wei, Duan Xiuying, Fang Xuefei, Shang Weina, Tong Chao

Abstract excerpt

Neurodegeneration is characterized by protein aggregate deposits and mitochondrial malfunction. Reduction in Tom40 (translocase of outer membrane 40) expression, a key subunit of the translocase of the outer mitochondrial membrane complex, led to accumulation of ubiquitin (Ub)-positive protein aggregates engulfed by Atg8a-positive membranes. Other macroautophagy markers were also abnormally accumulated. Autophagy...

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Source

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Identifiers

PMID: 29909722
DOI: 10.1080/15548627.2018.1474991
PMCID: PMC6208451

Genes

HDAC6
MTPAP
PINK1
PRKN
PTEN
ZFYVE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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