Article

ATPase Thorase Deficiency Causes α-synucleinopathy and Parkinson’s Disease-Like Behavior by Impairing PINK1/Parkin-Mediated Mitophagy

2022-05-12

Abstract excerpt

<title>Abstract</title> <p>Mitophagy is essential for the maintenance of mitochondrial quality control (MQC) and neuronal survival. Defects in mitophagy have been implicated in the onset and progression of Parkinson’s disease (PD). However, the underlying mechanisms of mitophagy in the pathogenesis of PD remains unclear. Here, the AAA+ ATPase Thorase was identified being essential for mitophagy. Mice lacking Thor...

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Literature Corpus work: 9ca59f17-b164-54dd-bed2-c0a2c6923eeb
DOI: 10.21203/rs.3.rs-1613050/v1

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