Article

Karyotypic divergence confounds cellular phenotypes in large pharmacogenomic studies

2019-03-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Somatic copy-number alterations that affect large genomic regions are a major source of genomic diversity in cancer and can impact cellular phenotypes. Clonal heterogeneity within cancer cell lines can affect phenotypic presentation, including drug response. <h4>Methods</h4> We aggregated and analyzed SNP and copy number profiles from six pharmacogenomic datasets encompassi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 386677c6-f6c2-528c-b038-32ced529c99d
DOI: 10.1101/574350

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Karyotypic divergence confounds cellular phenotypes in large pharmacogenomic studiesDOI 10.1101/574350Read

In Search of the Perfect Model: How Cancer Cell Lines Relate to Native CancersSemantic proximity Read

In Search of the Perfect Model: How Cancer Cell Lines Relate to Native CancersSemantic proximity Read

CNpare: matching DNA copy number profilesSemantic proximity Read

cancercelllines.org-a novel resource for genomic variants in cancer cell lines.Semantic proximity Read

A dynamic database of microarray-characterized cell lines with various cytogenetic and genomic backgrounds.Semantic proximity Read

Evaluating cell lines as tumour models by comparison of genomic profiles.Semantic proximity Read

Resolving sub-clonal heterogeneity within cell-line growths by single cell sequencing genomic DNASemantic proximity Read

Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology.Semantic proximity Read

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.Semantic proximity Read

Copy number variation heterogeneity reveals biological inconsistency in hierarchical cancer classificationsSemantic proximity Read

Genetic and transcriptional evolution alters cancer cell line drug response.Semantic proximity Read

Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60.Semantic proximity Read