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Article

Evaluating cell lines as tumour models by comparison of genomic profiles.

Nature communications - 1 Jan 2013

Domcke Silvia, Sinha Rileen, Levine Douglas A, Sander Chris, Schultz Nikolaus

Abstract excerpt

Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour samples from the Cancer Genome Atlas now allow a systematic genomic comparison of cell lines and tumours. Here we analyse a panel of 47 ovarian cancer cell lines and identify those that have the highest genetic similarity to ovarian...

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Identifiers

PMID: 23839242
DOI: 10.1038/ncomms3126
PMCID: PMC3715866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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