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Article

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Scientific reports - 26 Jul 2016

Kleensang Andre, Vantangoli Marguerite M, Odwin-DaCosta Shelly, Andersen Melvin E, Boekelheide Kim, Bouhifd Mounir, Fornace Albert J, Li Heng-Hong, Livi Carolina B, Madnick Samantha, Maertens Alexandra, Rosenberg Michael, Yager James D, Zhao Liang, Hartung Thomas

Abstract excerpt

Common recommendations for cell line authentication, annotation and quality control fall short addressing genetic heterogeneity. Within the Human Toxome Project, we demonstrate that there can be marked cellular and phenotypic heterogeneity in a single batch of the human breast adenocarcinoma cell line MCF-7 obtained directly from a cell bank that are invisible with the usual cell authentication by short tandem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27456714
DOI: 10.1038/srep28994
PMCID: PMC4960662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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