Article
Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology.
International journal of molecular sciences - 26 Feb 2020
Zolotovskaia Marianna A, Sorokin Maxim I, Petrov Ivan V, Poddubskaya Elena V, Moiseev Alexey A, Sekacheva Marina I, Borisov Nicolas M, Tkachev Victor S, Garazha Andrew V, Kaprin Andrey D, Shegay Peter V, Giese Alf, Kim Ella, Roumiantsev Sergey A, Buzdin Anton A
Abstract excerpt
Inter-patient molecular heterogeneity is the major declared driver of an expanding variety of anticancer drugs and personalizing their prescriptions. Here, we compared interpatient molecular heterogeneities of tumors and repertoires of drugs or their molecular targets currently in use in clinical oncology. We estimated molecular heterogeneity using genomic (whole exome sequencing) and transcriptomic (RNA...
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