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The <i>Pgb1</i> locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive function

2023-11-22

Abstract excerpt

In aged humans and mice, aggregates of hypobranched glycogen molecules called polyglucosan bodies (PGBs) accumulate in hippocampal astrocytes. PGBs are known to drive cognitive decline in neurological diseases but remain largely unstudied in the context of typical brain aging. Here, we show that PGBs arise in autophagy-dysregulated astrocytes of the aged C57BL/6J mouse hippocampus. To map the genetic cause of age-...

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Identifiers and source

Literature Corpus work
97e1ea6c-0783-5fb8-bad0-79a9f4431252
DOI
10.1101/2023.11.22.567373
Open publication

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The <i>Pgb1</i> locus controls glycogen aggregation in astrocytes of the aged hippocampus without impacting cognitive functionDOI 10.1101/2023.11.22.567373
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