Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer.

doi:10.1038/nm.4053

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Article

Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer.

Nature medicine - 1 Apr 2016

Kumar Akash, Coleman Ilsa, Morrissey Colm, Zhang Xiaotun, True Lawrence D, Gulati Roman, Etzioni Ruth, Bolouri Hamid, Montgomery Bruce, White Thomas, Lucas Jared M, Brown Lisha G, Dumpit Ruth F, DeSarkar Navonil, Higano Celestia, Yu Evan Y, Coleman Roger, Schultz Nikolaus, Fang Min, Lange Paul H, Shendure Jay, Vessella Robert L, Nelson Peter S

Abstract excerpt

Tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in an individual, we analyzed multiple tumors from men with disseminated prostate cancer through whole-exome sequencing, array...

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PMID: 26928463
DOI: 10.1038/nm.4053
PMCID: PMC5045679

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