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Article

Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction.

Nature cardiovascular research - 1 Mar 2025

Rasooly Danielle, Giambartolomei Claudia, Peloso Gina M, Dashti Hesam, Ferolito Brian R, Golden Daniel, Horimoto Andrea R V R, Pietzner Maik, Farber-Eger Eric H, Wells Quinn Stanton, Bini Giorgio, Proietti Gabriele, Tartaglia Gian Gaetano, Kosik Nicole M, Wilson Peter W F, Phillips Lawrence S, Munroe Patricia B, Petersen Steffen E, Cho Kelly, Gaziano J Michael, Leach Andrew R, Whittaker John, Langenberg Claudia, Aung Nay, Sun Yan V, Pereira Alexandre C, Casas Juan P, Joseph Jacob

Abstract excerpt

Heart failure (HF) has limited therapeutic options. In this study, we differentiated the pathophysiological underpinnings of the HF subtypes-HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF)-and uncovered subtype-specific therapeutic strategies. We investigated the causal roles of the human proteome and transcriptome using Mendelian randomization on more than 420,000...

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PMID: 39915329
DOI: 10.1038/s44161-025-00609-1
PMCID: PMC13214498

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ADM
EDNRA
IL6R
LPA

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