Mendelian Randomization of Circulating Proteome Identifies Actionable Targets in Heart Failure

Abstract excerpt

<h4>Background: </h4> Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide genetic association data for HF including 47,309 cases and 930,014 controls. We performed two-sample Mendelian randomization (MR) with multiple cis instruments as well...

Topics

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• Genome-Wide Association Study
• Heart Failure
• Inflammation
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide
• Proteome
• Proteomics
• Risk Factors

Identifiers and source

Literature Corpus work

3ed39676-50e9-5809-bcf4-089bb995a0e9

DOI

10.21203/rs.3.rs-1547537/v1